Ventoluft Polyherbal formulation modulates Freund’s Complete Adjuvant induced arthritis in experimental rats

Background: Ventoluft Polyherbal formulation composes multiple traditional medicinal plants composed of various anti-inflammatory agents. Hence, the present study aimed to investigate effect on Freund’s complete adjuvant-induced arthritic male Wistar rats. Materials and methods: The included thirty-six rats, containing six in each. Arthritis was induced by injecting FCA (0.1ml) joints right sub-plantar region rats negative control all test groups i.e. (20, 40, 80mg/kg p.o) for 28 days except normal group. A positive control, indomethacin (10mg/kg, i.p.) also tested days. During treatment, paw volume measured weekly once. At end experiment, physical, hematological, biochemical effects were evaluated. Results:Administration at doses 20, 80 mg/kg b.w. p.o exhibited statistically significant (p < 0.001) inhibition edema joint swelling, along with an increase body weight, decrease rheumatoid spleen index factors. Conclusion: results from hematological parameters have shown that possesses potent anti-arthritic activity, Results obtained indicate has exhibited, dose-dependent improvement arthritis.